Found 658 hits of ic50 data for polymerid = 4344,6096 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640273
(2-Cyclobutoxy-4-{6-[2-(7-methoxy-5-methyl-2,3-dihy...)Show SMILES COc1cc2OCCOc2c(C)c1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(OC2CCC2)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639887
(3-Ethoxy-5-{6-[2-(6-methoxy-4-methyl-benzofuran-5-...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2c(C)c3ccoc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639918
(3-Ethoxy-5-{6-[2-(7-ethoxy-2,3-dihydro-benzo[1,4]d...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc3OCCOc3cc2OCC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640100
(2-Ethoxy-4-{6-[2-(6-methoxy-4-methyl-benzofuran-5-...)Show SMILES CCOc1cc(ccc1C(O)=O)-c1cc(NCCc2c(C)c3ccoc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639883
(3-Ethoxy-5-{6-[2-(6-methoxy-benzo[b]thiophen-5-yl)...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc3ccsc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640277
(4-{6-[2-(7-Methoxy-5-methyl-2,3-dihydro-benzo[1,4]...)Show SMILES COc1cc2OCCOc2c(C)c1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(SC)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50092618
(CHEMBL3586362)Show SMILES C[C@@H]1COc2c(Cl)cc(cc2CN1Cc1cc[nH]c(=O)c1)-n1ccc2cc(F)ccc12 |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay |
J Med Chem 58: 5256-73 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00567
BindingDB Entry DOI: 10.7270/Q2416ZSC |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM35847
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
PDB
Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method |
Bioorg Med Chem 25: 471-482 (2017)
Article DOI: 10.1016/j.bmc.2016.11.014
BindingDB Entry DOI: 10.7270/Q2CF9S3S |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM35847
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
PDB
Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells |
Bioorg Med Chem 24: 1793-810 (2016)
Article DOI: 10.1016/j.bmc.2016.03.006
BindingDB Entry DOI: 10.7270/Q2J67JS7 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639891
(3-Ethoxy-5-{6-[2-(6-methoxy-benzofuran-5-yl)-ethyl...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc3ccoc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639897
(4-{6-[2-(6-Methoxy-benzo[b]thiophen-5-yl)-ethylami...)Show SMILES COc1cc2sccc2cc1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(SC)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM35847
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
PDB
Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
UBE Industries, Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting |
J Med Chem 61: 6869-6891 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00808
BindingDB Entry DOI: 10.7270/Q2125WXC |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Prostaglandin E2 receptor EP2 subtype
(Mus musculus (Mouse)) | BDBM50092616
(CHEMBL3586360)Show SMILES Fc1ccc2n(ccc2c1)-c1cc(Cl)c2OCCN(Cc3cc[nH]c(=O)c3)Cc2c1 Show InChI InChI=1S/C23H19ClFN3O2/c24-20-12-19(28-6-4-16-10-18(25)1-2-21(16)28)11-17-14-27(7-8-30-23(17)20)13-15-3-5-26-22(29)9-15/h1-6,9-12H,7-8,13-14H2,(H,26,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production |
J Med Chem 58: 5256-73 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00567
BindingDB Entry DOI: 10.7270/Q2416ZSC |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640016
(4-{6-[2-(7-Ethoxy-2,3-dihydro-benzo[1,4]dioxin-6-y...)Show SMILES CCOc1cc2OCCOc2cc1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(SC)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640272
(2-Ethoxy-4-{6-[2-(7-methoxy-5-methyl-2,3-dihydro-b...)Show SMILES CCOc1cc(ccc1C(O)=O)-c1cc(NCCc2c(C)c3OCCOc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640087
(2-Cyclobutoxy-4-{6-[2-(6-methoxy-4-methyl-benzofur...)Show SMILES COc1cc2occc2c(C)c1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(OC2CCC2)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640005
(2-Ethoxy-4-{6-[2-(6-ethoxy-benzo[b]thiophen-5-yl)-...)Show SMILES CCOc1cc2sccc2cc1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(OCC)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640244
(3-Ethoxy-5-{6-[2-(4-fluoro-benzo[b]thiophen-5-yl)-...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2ccc3sccc3c2F)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639981
((2-Ethoxy-4-{6-[2-(6-methoxy-4-methyl-benzofuran-5...)Show SMILES CCOc1cc(ccc1OCC(O)=O)-c1cc(NCCc2c(C)c3ccoc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640305
((4-{6-[2-(7-Methoxy-5-methyl-2,3-dihydro-benzo[1,4...)Show SMILES COc1cc2OCCOc2c(C)c1CCNc1cc(ncn1)-c1ccc(CC(O)=O)c(OC(F)(F)F)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640282
(4-{6-[2-(7-Fluoro-6-methoxy-benzo[b]thiophen-5-yl)...)Show SMILES COc1c(CCNc2cc(ncn2)-c2ccc(C(O)=O)c(SC)c2)cc2ccsc2c1F | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639913
(3-Ethoxy-5-{6-[2-(6-methyl-benzo[b]thiophen-5-yl)-...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc3ccsc3cc2C)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639928
(3-Ethoxy-5-{6-[2-(6-methoxy-benzo[1,3]dioxol-5-yl)...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc3OCOc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50092616
(CHEMBL3586360)Show SMILES Fc1ccc2n(ccc2c1)-c1cc(Cl)c2OCCN(Cc3cc[nH]c(=O)c3)Cc2c1 Show InChI InChI=1S/C23H19ClFN3O2/c24-20-12-19(28-6-4-16-10-18(25)1-2-21(16)28)11-17-14-27(7-8-30-23(17)20)13-15-3-5-26-22(29)9-15/h1-6,9-12H,7-8,13-14H2,(H,26,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay |
J Med Chem 58: 5256-73 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00567
BindingDB Entry DOI: 10.7270/Q2416ZSC |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50092615
(CHEMBL3586361)Show SMILES C[C@@H]1COc2c(Cl)cc(cc2CN1Cc1cc[nH]c(=O)c1)-c1csc2ccccc12 |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay |
J Med Chem 58: 5256-73 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00567
BindingDB Entry DOI: 10.7270/Q2416ZSC |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639880
(3-Ethoxy-5-{6-[2-(3-methoxy-1-methyl-naphthalen-2-...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2c(C)c3ccccc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640246
(4-{6-[2-(4-Fluoro-benzo[b]thiophen-5-yl)-ethylamin...)Show SMILES CSc1cc(ccc1C(O)=O)-c1cc(NCCc2ccc3sccc3c2F)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Mus musculus (Mouse)) | BDBM50092616
(CHEMBL3586360)Show SMILES Fc1ccc2n(ccc2c1)-c1cc(Cl)c2OCCN(Cc3cc[nH]c(=O)c3)Cc2c1 Show InChI InChI=1S/C23H19ClFN3O2/c24-20-12-19(28-6-4-16-10-18(25)1-2-21(16)28)11-17-14-27(7-8-30-23(17)20)13-15-3-5-26-22(29)9-15/h1-6,9-12H,7-8,13-14H2,(H,26,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay |
J Med Chem 58: 5256-73 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00567
BindingDB Entry DOI: 10.7270/Q2416ZSC |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640309
(2-Isopropoxy-4-{6-[2-(7-methoxy-5-methyl-2,3-dihyd...)Show SMILES COc1cc2OCCOc2c(C)c1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(OC(C)C)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50506546
(Omidenepag | UR-7276)Show SMILES OC(=O)CNc1cccc(CN(Cc2ccc(cc2)-n2cccn2)S(=O)(=O)c2cccnc2)n1 Show InChI InChI=1S/C23H22N6O4S/c30-23(31)15-25-22-6-1-4-19(27-22)17-28(34(32,33)21-5-2-11-24-14-21)16-18-7-9-20(10-8-18)29-13-3-12-26-29/h1-14H,15-17H2,(H,25,27)(H,30,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
UBE Industries, Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting |
J Med Chem 61: 6869-6891 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00808
BindingDB Entry DOI: 10.7270/Q2125WXC |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50092618
(CHEMBL3586362)Show SMILES C[C@@H]1COc2c(Cl)cc(cc2CN1Cc1cc[nH]c(=O)c1)-n1ccc2cc(F)ccc12 |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production |
J Med Chem 58: 5256-73 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00567
BindingDB Entry DOI: 10.7270/Q2416ZSC |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639899
(3-Ethoxy-5-{6-[2-(4-methyl-benzo[b]thiophen-5-yl)-...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2ccc3sccc3c2C)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639988
(2-Ethoxy-4-{6-[2-(6-methoxy-benzo[b]thiophen-5-yl)...)Show SMILES CCOc1cc(ccc1C(O)=O)-c1cc(NCCc2cc3ccsc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639932
((2-Ethoxy-4-{6-[2-(6-ethoxy-benzo[b]thiophen-5-yl)...)Show SMILES CCOc1cc(ccc1OCC(O)=O)-c1cc(NCCc2cc3ccsc3cc2OCC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639886
(3-Ethoxy-5-{6-[2-(1-methyl-naphthalen-2-yl)-ethyla...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2ccc3ccccc3c2C)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640072
(4-{6-[2-(6-Methoxy-benzofuran-5-yl)-ethylamino]-py...)Show SMILES COc1cc2occc2cc1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(SC)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639942
(2-Cyclobutoxy-4-{6-[2-(6-methoxy-benzo[b]thiophen-...)Show SMILES COc1cc2sccc2cc1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(OC2CCC2)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639983
(3-Ethoxy-5-{6-[2-(7-fluoro-4-methyl-3,4-dihydro-2H...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc3N(C)CCOc3cc2F)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639978
((2-Ethoxy-4-{6-[2-(7-ethoxy-2,3-dihydro-benzo[1,4]...)Show SMILES CCOc1cc2OCCOc2cc1CCNc1cc(ncn1)-c1ccc(OCC(O)=O)c(OCC)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640156
(4-{6-[2-(6-Methoxy-benzo[1,3]dioxol-5-yl)-ethylami...)Show SMILES COc1cc2OCOc2cc1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(SC)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639909
(3-Ethoxy-5-{6-[2-(7-methyl-2,3-dihydro-benzo[1,4]d...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc3OCCOc3cc2C)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639892
(3-Ethoxy-5-{6-[2-(6-fluoro-benzofuran-5-yl)-ethyla...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc3ccoc3cc2F)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640324
(2-Cyclopropoxy-4-{6-[2-(7-ethoxy-2,3-dihydro-benzo...)Show SMILES CCOc1cc2OCCOc2cc1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(OC2CC2)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640037
(2-Ethylsulfanyl-4-{6-[2-(6-methoxy-benzofuran-5-yl...)Show SMILES CCSc1cc(ccc1C(O)=O)-c1cc(NCCc2cc3ccoc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640304
((4-{6-[2-(7-Ethoxy-2,3-dihydro-benzo[1,4]dioxin-6-...)Show SMILES CCOc1cc2OCCOc2cc1CCNc1cc(ncn1)-c1ccc(CC(O)=O)c(OC(F)(F)F)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640069
(4-{6-[2-(6-Methyl-benzo[b]thiophen-5-yl)-ethylamin...)Show SMILES CSc1cc(ccc1C(O)=O)-c1cc(NCCc2cc3ccsc3cc2C)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639938
(4-{6-[2-(3-Methoxy-1-methyl-naphthalen-2-yl)-ethyl...)Show SMILES COc1cc2ccccc2c(C)c1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(SC)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639902
(3-Ethoxy-5-{6-[2-(3-ethoxy-naphthalen-2-yl)-ethyla...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc3ccccc3cc2OCC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639906
(5-{6-[2-(3-Cyano-benzo[b]thiophen-5-yl)-ethylamino...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2ccc3scc(C#N)c3c2)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639905
(3-Ethoxy-5-{6-[2-(7-methoxy-2,3-dihydro-benzo[1,4]...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc3OCCOc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
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